Searchable abstracts of presentations at key conferences in endocrinology

ea0032oc2.2 | Bone & Calcium | ECE2013

Influence of vitamin D and calcium on reproductive hormones: a study in a VDR-ablated male mouse model and 300 healthy men

Jensen Martin Blomberg , Lieben Liesbet , Nielsen John E , Willems Ariane , Juul Anders , Jorgensen Niels , Toppari Jorma , Carmeliet Geert , Rajpert-De Meyts Ewa

Introduction: Vitamin D (VD) is metabolized locally in the testis, and ablation of the VD receptor (Vdr−/−) in mice has proven a valid model for hereditary VD resistant rickets. However, only one of three published Vdr−/− strains presented with male infertility. Here, we investigated reproductive hormones, gene expression and the testicular histological phenotype of male Vdr−/−mice,...